Semaglutide vs. Tirzepatide
Understanding Your GLP-1 Options
Semaglutide
The proven standard. Reliable, steady fat loss on a molecule with years of results behind it.
$249/month
Tirzepatide
The heavy hitter. Dual-pathway action for maximum appetite control and output.
$349/month
Clinical perspective
So which one is better?
Honest answer: neither, universally. Tirzepatide tends to produce greater weight loss for many patients thanks to its dual-hormone action. Semaglutide remains a proven, reliable workhorse at a lower price point.
What matters is your body, your goals, and your budget — and you're the one who weighs those. Pick the molecule that fits. Your clinician confirms it's medically appropriate and dials in your dose.
And nothing is locked in. If you plateau or your goals change, switching between the two is straightforward and handled through your portal.
Your decision, backed by us
You make the call
Semaglutide or tirzepatide — the choice is yours. This page gives you the full picture so you can make it with confidence.
We confirm it's right for you
A licensed clinician reviews your health history and medications to make sure your choice is safe — then doses it specifically for you.
Change your mind anytime
Not locked in. Switch molecules, adjust dosing, or pause — handled through your patient portal.
Dr. Michael Green
Chief Medical Officer
Know your options
What each molecule is, how it works, and what it may support — side by side, top to bottom.
Semaglutide
GLP-1 receptor agonist
Mimics a natural hormone released after you eat. It tells your brain you're full, slows digestion, and supports healthy blood sugar — so eating less stops feeling like a fight.
How it works
- Targets the hormone that regulates hunger and fullness
- Activates appetite-control signals in the brain
- Slows how quickly food leaves your stomach
The benefits
Reduces appetite and cravings
Quiets the constant pull toward food so a calorie deficit stops taking willpower.
Fuller sooner, fuller longer
Slower digestion means smaller portions actually satisfy you.
Tirzepatide
GLP-1 + GIP dual agonist
Activates two metabolic hormone receptors instead of one. The added GIP pathway amplifies appetite control and fullness, which is why it tends to drive greater weight loss for many patients.
How it works
- Activates two hormone receptors — GLP-1 and GIP
- Works across multiple pathways involved in metabolism
- Hits food noise and cravings harder
The benefits
Stronger appetite suppression
Dual-hormone signaling hits hunger from two directions at once.
Greater average weight loss
In clinical research, tirzepatide has generally produced larger reductions.
*These statements describe potential benefits and are not a guarantee of individual results.
Side by side
Same weekly rhythm, same clinical oversight — different mechanisms and price points.
Semaglutide
Tirzepatide
What it is
GLP-1 receptor agonist
GLP-1 + GIP dual agonist
How it works
Signals fullness, slows digestion, quiets food noise
Hits two metabolic pathways for stronger appetite control
Best for
Steady, proven fat loss
Maximum results, faster
Dosing
Once-weekly injection
Once-weekly injection
Needle-free option
Available
—
First month
$189
$249
Ongoing
$249/mo
$349/mo
Pricing varies with treatment plan and dosage. HSA / FSA eligible.
Included with every plan
Whichever molecule you land on, the care around it is identical.
- Medical evaluation and a personalized treatment plan
- Medication dosed and titrated to you
- Unlimited access to your Maves clinician
- 24/7 support from your care team
- Free & discreet shipping
Dosing
Both follow the same clinician-guided rhythm. Only one skips the needle.
Semaglutide
- Once-weekly, self-administered
- Gradual dose increase to minimize side effects
- Clinician-guided titration and check-ins
- Needle-free option available
Tirzepatide
- Once-weekly, self-administered
- Gradual dose increase to minimize side effects
- Clinician-guided titration and check-ins
- Needle-free option available (not available)
Side effects: the honest rundown
Common effects with both medications are usually mild and temporary while your body adapts. They may include:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal discomfort
- Decreased appetite
- Indigestion
- Injection-site redness
Most symptoms fade as your body adjusts. Both medications start low and titrate up gradually to keep this manageable — and your care team is one message away if anything persists or worsens.
Better together
GLP-1s work even better paired
In the Body Recomp Protocol, GLP-1 cuts the fat while Sermorelin protects the muscle underneath — the two-treatment stack most clinics never prescribe.
The protocol
2-in-1GLP-1 Therapy
Semaglutide or Tirzepatide
Sermorelin
Performance Protocol
Verified results
Thousands of patients. Real progress.
57,000+ patients
“Recovery feels faster, sleep feels deeper.”
“Finally seeing progress that sticks.”
“Strength stayed, fat dropped—exactly what I wanted.”
“Feels designed for people who take health seriously.”
“Weight loss without the crash or burnout.”
“Helped me reset habits without extreme dieting.”
“Leaned out and kept my strength. That’s rare.”
“I feel sharper in the gym and outside it.”
“Support and care actually feel personal.”
Individual results vary. Testimonials reflect personal experience and are not a guarantee of outcomes.
Frequently Asked Questions
Everything you need to know
Semaglutide activates one hormone receptor, GLP-1. Tirzepatide activates two, GLP-1 and GIP. Both signal fullness, slow digestion and quiet food noise; tirzepatide's second pathway tends to make appetite control stronger, which is why it generally produces greater weight loss, and why it costs more.
In clinical research, tirzepatide has generally produced larger average reductions. Individual results vary: many patients reach their goals on semaglutide, and your response, your budget and how you tolerate each medication matter as much as the average.
Yes. If you plateau or your goals change, your clinician can move you from one to the other. The switch is handled through your patient portal, and your dose is re-titrated for the new medication.
Both share the same profile. Nausea, vomiting, diarrhea, constipation, abdominal discomfort, decreased appetite, indigestion and injection-site redness are the most common, and they are usually mild and fade as your body adjusts. Starting low and increasing gradually keeps them manageable, and your care team is one message away if anything persists.
You do, with a clinician confirming it. Pick the molecule that fits your goals and budget; a licensed clinician reviews your health history and medications to make sure it is safe for you, then sets and adjusts your dose.
Still have questions?
Our team is happy to help
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Prescription products require an online consultation with a licensed healthcare provider who will determine if a prescription is appropriate. Individual results vary and are not guaranteed.
Am I eligible?
One consult answers it.
Every metabolism and health history is different. A licensed clinician reviews your medications, goals, and labs — and if treatment fits, your plan is dosed specifically for you.
- No commitment
- Free online consultation
Am I eligible? One consult answers it.
Every metabolism and health history is different. A licensed clinician reviews your medications, goals, and labs — and if treatment fits, your plan is dosed specifically for you.
- No commitment
- Free online consultation
